Organ transplant – scientists regenerate pig organs an hour after death

Scientists from Yale University in the US were able to partially restore the viability of the organs of a pig an hour after the animal died. How informs Air Force, this is a breakthrough that could further increase the number of organs available to people for transplants and give doctors more time to save lives.

Read also: Scientists reveal where COVID-19 first appeared

Scientists’ research is also changing the idea of ​​what happens between life and death. Experts note that the discovery is “really outstanding” and “incredibly important.”

When the heart stops beating, the body lacks the oxygen and other nutrients it needs to survive. Organs increase in size, blood vessels collapse, and cells begin to die.

It was thought that this cell death happened once and for all, but now scientists have managed to repair some of the damage in the organs of animals that have been dead for an hour.

“We can restore some cell function in many vital organs that should have been dead. These cells function a few hours after they shouldn’t,” said Prof. Nenad Sestan.

In 2019, scientists managed to do something similar, but with the brain of a pig. Now a technology called OrganEx has been adapted to work with the whole body.

The researchers used synthetic blood to carry oxygen around the body. Such blood does not clot, so it can move through the collapsing blood vessels of the pig. In addition, the scientists introduced a cocktail of 13 compounds to interrupt chemical processes that end in cell death, as well as a device to pump blood throughout the body to mimic a beating heart.

The experiments, the results of which were published in the journal Nature, involved 100 pigs. Conducting such experiments was approved on the basis of ethical considerations.

The researchers put the animals into a deep sleep and stopped their hearts. After they had been in this state for more than an hour, they were connected to the OrganEx system and given a restorative cocktail for six hours. At the same time, throughout the experiment, the animals continued to be given anesthesia.

Six hours later, scientists dissected the pigs and found that organs such as the heart, liver and kidneys partially recovered and were able to regain some functionality.

The electrical activity in the heart was restored, the heart muscle could contract, but the organs did not function at the same level as in life.

Previously scientists from the Weizmann Institute in Israel were the first in the world to create “synthetic embryos”. At the same time, the researchers did not need sperm, eggs and the fertilization process.

Leave a Reply

Your email address will not be published.

Back to top button